This is one of a series of 10 talks given at an integrative conference held in Fulda, German in December 2013. The conference was organised and sponsored by Dr Reinwald of Dr Reinwald Healthcare GmBH and manufacturers of Master Amino Acid Pattern (MAP-Product Info-Basic-E-Web (1) Copy), a nutritional supplement.
Dr John Ionescu graduated with a doctoral degree in medical biochemistry from the University of Saabrucken in 1983. He was research director in a German dermatology clinic in 1985. In 1986, he was the director of a clinic for nutritional and environmental medicine in Neukirchen. He holds memberships in the European Academy of Allergy and Clinical Immunology, the American Academy of Environmental Medicine, German Society of Anti-Aging Medicine, European Academy of Environmental Medicine. He is Associate Professor for integrative medicine and gerontology at the Carol Davila University (Bucharest), and lecturer in clinical nutrition at the Danube University Krems (Vienna). Since 2009 he has been a member of the task force for environmental medicine at the German Ministry of Health (Berlin).
I found this talk a steep learning curve in terms of technical knowledge, and had to dredge up my memories of ‘O’ level chemistry on chemical reactions – reduction and oxidation – and also to go onto YouTube for some refreshers. I’m not sure if I’ve got to the bottom of the talk yet, so it’s a work-in-progress.
The layman’s main points-of-interests are:
1. Redox is a natural state of being – whenever oxygen is used there is an exchange of molecules in a process called reduction and oxidation. One substance is reduced and one will be oxidised. Heavy metals cause oxydosis. Free radicals are created as a result of the process of redox. The aim is to minimise any damage caused by unfettered free radical creation.
Amazingly, cancer cells are always alkaline and in a redosis state. They thrive in an acidic environment.
In his talk Dr Ionnescu shows that there are ways of measuring the redox values of various treatments (i.e. the effectiveness of a treatment in reducing redox damage), e.g. exercise, sauna, juices, fasting, hyperthermia, IV C and supplements.
2. Glutathione is not beneficial to cancer patients – this was a bit of a shocker as I have been given glutathione in infusions. And never use GSH and IV C together as it blocks the absorption of the ascorbic acid.
3. Re. juices: beetroot juice is not good for cancer patients – something Gerson wasn’t aware of. Carrot juice is good.
4. Beware iron – it stimulates cancer cells.
Classification of disturbances of Acid-Base and Redox Balance
Heavy metals = oxydosis
Redosis = Eh Low, PO2 Low – increased non volatile reductant – dreased nonvolatile oxidant = hypoxia (lacking oxygen) = Warburg effect + glycolysis and because reductive elements cannot be burned.
Vitamin E – increased levels of transitional metals in breast cancer tissue.
What is in cancer cells that cause the change?
Use of Prague study and Karolinska Institute – heavy metals and transition metals – tumours accumulate other electron-taking chemicals, BPA, pesticides. Solvents, dental amalgams (use gas chromatography), environmental toxins. Associated with Phase 2 detox deficit – cannot detoxify these elements.
Why are some people more sensitive to environmental diseases?
– Google “Environmental Hospital/Clinic”
– outside cancer cells = acidosis
-inside cancer cells = alkaline
How metastasis is increased
– Zinc is detrimental to cancer patients (?)
– Bicarbonate increases tumour pH and inhibits spontaneous metastasis.
Diseases associated with metabolic redosis
– allergies, infections, psoriasis, cancer
– Selenium deficiency. thyroid T4 to T3 conversion
– cancer cells are always alkaline and in a redosis state. Anaerobic glycolysis. Embryonic cells are in a redosis state
– The role of ph dynamics and the Na+/H antiporter system – NA+ goes into cells and H+ causes acidosis
How to enhance chemotherapy by manipulation of tumour pH
– Hypoxia-inducible factor 1 – strong promoter of alkalinisating genes (CypB) – maintains alkaline state – leads to acidification of outside of cell.
– Tumour cells prefer glucose. Therefore must decrease insulin release e.g. through ketogenic diet.
– There are 50 times more glucose receptors on cancer cells
– Cancer cells do not allow pyruvate dehydrogenase kinase – converted into lactase.
– MCT system
– do not use glutathione plus chemotherapy – causes resistance in cancer cells!!!
– Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional activator. (from http://www.ncbi.nlm.nih.gov/pubmed/16887934)
– HIF-1 – Exercise plays an important role – without = hypoxia
HIF-1 mediates adaptation to hypoxia by actively downregulating mitchondrial oxygen consumption
Slide: Cell Metabolism 3, 187-197, March 2006
Pyruvate activates HIF1 and therefore it’s a vicious cycle and the cancer cell can maintain itself.
– the Pentose Phosphate pathway: an antixoidant defense and a cross-road in tumour cell fate – Dr Coy – Oncogene (2006) 25, 4633-4646
– there is a strong Warburg effect in metastases.
Slide: Glycolysis inhibition for anticancer treatment
Transketolase-1 protein overexpression: a potential biomarker and therapeutic target in breast cancer
– TKTL1 positive and TKTL1 negative
– When TKTL1 negative – survival rate of 80% over 5 years
1. e.g. short fasting (3-5 days) plus juices – induces ketosis
– use of butyric acid
– Limits of fasting – not all patients of Gerson who underwent fasting and juices survived
2. Exercise – pro-oxidative – 15 minutes of jogging moves minus 120mv to minus 111
3. Sauna/hyperthermia – sauna moves redox from minus 109 to minus 96 mv. Hyperthermia moves redox from minus 43 to minus 18 to minus 15
4. Hydrogen peroxide treatment – minus 127mv to minus 4mv
5. Dioxychlorate – redosis of the body – minus 135mv to minus 118mv
6. Juices – which ones? Carrot juice is pro-oxidative and moves from minus 128 to minus 111 mv. Polyphenols in blueberries and celery.
– Beetroot juice is not good for cancer – pro-reductive effect. Unfortunately, Gerson didn’t know this.
– Citrus fruit – grapefruit – polyphenols – move from minus 93 to minus 68
– Every food changes everything. Must start with a fasted patient.
8.5g infusion IVC – moved from minus 127mv to minus 103 mv in 15 minutes, to minus 77 mv in 5 hours, to minus 62mv in 6 hours – massive oxidation
– Redox cycle and catabolic pathways of ascorbic acid
Iron (F3) and ascorbate-induced free radical Vitamin C
– prolongation of survival times in terminal human cancer
– iron content in breast cancer – 20% decrease iron in normal cells
– cancer cells also need zinc to proliferate
What about anaemia?
– blood transfusions from relatives with fresh blood, not iron supplements.
– Super-oxi radical formation – induces apoptosis
Antioxidants e.g. Glutathione
Ascorbic Acid plus GSH do not provide any benefit
IV Ascorbic Acid + IV GSH not on same day – otherwise the AA ascorbate cannot be oxidised.
Polyphenols – EGCG
Why does skin cancer disappear?
– transcription factors NfkB reduced through ECGC
– redox system shows that EGCG have high redox potential – redox moves form minus 87 to minus 67.
“ABDE polyphenol mix”
Metals – Copper and iron added to the polyphenol state
– Metformin – inhibition of glycolysis
– Can patients have IV C with chemotherapy?
Yes, in between courses of chemotherapy
– curcumin – dose needs to be right. Curcumin IV for artery going to the tumour
8.5g iV C for environmental patients
50g IV C for cancer patients
measure redox values before and after treatment
– Sauna and ketogenic diet
– decrease glucose. Ketogenic diet has potentiating effect