Best of Breast: news for week ending 31 October 2014

New developments in Breast Cancer and Cancer from Google Alerts, for the week ending 31 October 2014.

We’re used to thinking of arsenic as a poison, so it comes as a surprise that arsenic in drinking water in a region in Chile has been linked to 50% lower deaths from breast cancer.

In case you were wondering where you can get hold of some arsenic, you don’t have to look any further than your supermarket:  according to a UK study, more than half the rice products in the EU exceed child safety limits for arsenic!

Talk about cereal killers!

lead_arsenic_poisoning

1.  Arsenic in drinking water linked to fewer breast cancer deaths

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Best of Breast: news for week ending 15 August 2014

A summary of medical developments in Breast Cancer and Cancer for the week ending 15 August 2014.

In Best of Breast w/e 8 August 2014 it was wasp venom that was being used to fight cancer, now it’s the turn of the bee.  OK, it’s not the most earth-shaking medical development, but it makes a change from the usual chemotherapy drugs.trials.  And speaking of which, Item 3 examines the fact that different chemotherapy regimes have different side effects, and raises the question that we should reconsider what choices are made in selecting treatments.

Item 2A is about a purported cure using salt injected directly into tumours.  Please note that this is not what it seems to be: an easy cure for cancer.  The refutation is in Item 2B, and highlights the need not to jump the gun or fall prey to so-called breakthroughs.  And this salt cure has nothing to do with Dr. Simoncini’s controversial work on bicarbonate of soda and tumours.

bee venom

How do you milk a bee? Answer: Very carefully! Today, the most widely is used the method of so-called “milking” the bees during the spring-summer season. In this case, the bees are annoyed by weak electric current pulses and sting a glass, from which the dried venom is then scraped. photo credit: keepingbee.org

1.  Bee, snake and scorpion venom could be used to fight cancer

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Best of Breast: news for week ending 17 January 2014

A summary of  Google Alerts for Breast Cancer and Cancer for the week ending 17 January 2014.

In previous posts, I’ve bemoaned the fact that scientists have already found cures for cancer, but unfortunately they are only at the premature rat-and-mouse trial stage.

This week, it’s the turn of the naked mole rat to take centre-stage. As you can see, it’s not going to win prizes for its looks, but I don’t care – I wish I were a naked mole rat.

naked-mole-rat0_2328106b

I may be ugly and I lisp, but I’ll never get canther!  (photo of naked mole rat)

Metastasis is the theme this week.

Scientists discover how cancer cells can turn themselves into brain cells to evade capture, and in yet another example of how evil and sneaky they are, transform into brain tumours.  It explains how people in remission can later develop brain tumours.  (Not helpful for the millions of women who already have brain tumours, but may lead to the development of treatments that will prevent such metastasis in other breast cancer patients.)

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Best of Breast: news for week ending 13 December 2013

A weekly round-up of Google Alerts on the latest medical developments in Breast Cancer.  I was puzzled as to why there was such a surge this week, and realised that it was due to studies being released at the San Antonio Breast Cancer symposium 2013 (http://www.sabcs.org/PressReleases/Documents/2013/b3c6acef3fe26baa.pdf)

There’s fantastic news that the aromatase inhibitor, anastrazole (aka Arimidex), can cut the risk of breast cancer in women by 50% and with fewer side-effects than drugs like tamoxifen.  But please note (and this is not being made clear in newspaper headlines), anastrozole is usually only used in post-menopausal women (because the ovaries in premenopausal women produce too much aromatase for the inhibitors to block effectively).  There’s also little discussion on the side-effects which may make it difficult for women to comply with taking the medication.

The FDA has issued a warning about nipple aspirate tests being used as a substitute for mammograms.  The message is:  they’re not reliable, and don’t.  They sound awfully like thermograms to me – I had a thermogram done about 3 days’ after my initial diagnosis, and the practitioner who conducted the test told me that without the mammogram, he wouldn’t have diagnosed breast cancer from my thermogram. (part of the issue is that the thermogram machines in the UK are not sophisticated enough to give the detailed results required for such diagnosis).

smart-bra

404 error … Windows cannot recognise the software … one or both servers is not working … please reinstall drivers … image credit: nytimes.com

1A.  Microsoft working on a smart bra that detects breast cancer and measures moods

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Best of Breast: news for week ending 1 November 2013

A sweep of the latest medical developments in breast cancer from Google Alerts, for the week ending 1 November 2013.

[Breast Cancer Awareness month is just about over, but Google Alerts is still top-heavy with first-person survival stories, and cancer fundraisers and tweeting bras, so if I’ve missed something out, my apologies. Please post any new developments that I’ve missed in the comments box and I’ll be glad to include them in the compilation, and include an acknowledgement of your contribution.]

DiscoveringHands

1.  German breast cancer detection tool employing blind women

OK, this isn’t an earth-shattering medical development or cure for cancer, but it’s an example of how we don’t always need expensive or sophisticated equipment to detect cancer.  This is a low-tech idea that can be used in countries where mammograms aren’t available.

http://www.heritagefl.com/story/2013/10/25/features/german-breast-cancer-detection-tool-employing-blind-women/1622.html

Discovering Hands, is a German programme that hopes to give blind women an opportunity for a life-changing career by turning their more acute sense of touch into a skilled breast tumor detection tool.

In the Medical Tactile Examination method, self-adhesive orientation stripes with tactile orientation points are attached to the patient’s breast in various positions, and the breast is divided into zones that allow the examiners to define the precise square centimeter where an abnormality is found. Unlike an exam by a doctor, an MTE breast examination takes between 30 to 60 minutes.

Discovering Hands conducted a study in conjunction with the University of Essen, looking at 451 patients that were examined by MTEs. Among these patients, there were 32 abnormal findings that were discovered by the MTEs but not by the doctors. “Women with those findings would have been sent home by the doctors,” Dr Hoffman, the physician in charge of the study, told JNS.org. A new peer review study will begin in November.”

Discovering Hands – website.

2.  Breast cancer ‘rising in under-40s’ across Europe

  • Cases of breast cancer in women under 40 are rising across Europe, research suggests.
  • Experts say it is unclear whether this is due to improved diagnosis or new risk factors.
  • A study in Cancer Epidemiology found cases rose by about 1% a year between 1990 and 2008 in seven countries.
  • Breast cancer is the most common cause of cancer among women globally, and the leading cause of cancer death.

3.  New breast cancer test that can detect seven types of the disease could lead to more personalised treatment for patients

http://www.dailymail.co.uk/health/article-2479451/Breast-cancer-test-detect-7-types-disease.html

  • Scientists looked for signature biomarkers in 1,073 tumour samples
  • Found that 93% of samples fitted into one of seven classes of breast cancer
  • Each cancer type has a different effect on patient survival
  • Last year researchers categorised 10 different forms of breast cancer based on their underlying gene defects. But they can only be identified using sophisticated genetic profiling, making this form of test for patients costly and impractical.
  • In contrast, the seven cancer test could be ready for use in the clinic in as little as two years, it is claimed.

4.  Hormone levels may help predict breast cancer risk

http://www.health24.com/Medical/Cancer/News/Hormone-levels-may-help-predict-breast-cancer-risk-20131031

Researchers report that doctors might better predict a woman’s risk for breast cancer by tracking levels of key hormones.

5.  UK-made drug blocks oestrogen production and may help prolong lives of post-menopausal women

http://www.dailymail.co.uk/health/article-2480649/UK-drug-irosusat-breast-cancer-lifeline.html

  • Drug irosusat is being trialled by patients in Liverpool and the Wirral
  •  Most breast cancers need oestrogen to grow and there are two ways  in which the body  can make it.
  • Currently, a hormone drug can block one of these ways, but with the introduction of irosustat, it is possible to block the other one.
  • If trials show the new pill is working it could be available within three years

6.  New nanoparticles treatment delivers one-two punch to triple-negative breast cancer

http://web.mit.edu/press/2013/one-two-punch-knocks-out-aggressive-tumors.html

Triple negative breast cancer is a very aggressive form of cancer that is very difficult to treat: Chemotherapy can shrink such tumors for a while, but in many patients they grow back and gain resistance to the original drugs.

To overcome that resistance, MIT chemical engineers have designed nanoparticles that carry the cancer drug doxorubicin, as well as short strands of RNA that can shut off one of the genes that cancer cells use to escape the drug. This “one-two punch” disables tumors’ defenses and makes them much more vulnerable to chemotherapy.

7A.  Radiation for breast cancer can increase heart risks

I don’t think this study is saying anything new:  it’s another case of weighing up the odds, and buying yourself time by taking your chances with radiotherapy and not dying of cancer.

http://www.health.harvard.edu/blog/radiation-for-breast-cancer-can-increase-heart-risks-2-201310306820

A new research letter published in JAMA Internal Medicine estimates that the increased lifetime risk for a heart attack or other major heart event in women who’ve had breast cancer radiation is between 0.5% and 3.5%. The risk is highest among women who get radiation to the left breast—understandable, since that’s where the heart is located.

The heart effects of radiation begin emerging as soon as five years after treatment, according to a large European study out earlier this year in The New England Journal of Medicine. That study also found that, for every 1 gray of radiation (a unit that measures the absorbed radiation dose), a woman’s heart risk rises by 7.4%.”

7B.  Healthy hearts handle breast cancer radiotherapy better

http://www.medpagetoday.com/Cardiology/Prevention/42534

“There really isn’t any safe dose at all,” Jean-Bernard Durand, MD, an associate professor in the department of cardiology at the University of Texas MD Anderson Cancer Center in Houston, told MedPage Today.

He suggested that radiation oncologists consider better ways to protect and shield the heart from radiation exposure and radiation scatter. Also, they should continue to work with cardiologists and internal medicine physicians following radiation therapy to ensure patients maintain a healthy lifestyle and are on optimal medical therapy for heart disease risk factors.

Radiotherapy-induced risks of major coronary events are likely to be reduced in these patients by targeting baseline cardiac risk factors (cholesterol, smoking, hypertension), by lifestyle modification, and/or by pharmacological treatment.