Best of Breast: news for week ending 7 November 2014

News for Breast Cancer and Cancer, from Google Alerts, for the week ending 7 November 2014.

[Apologies, I’m so behind in Best of Breast it’s no joke. I’ve been sorting out personal issues the past months which have taken priority.  Looks as though I’ll be spending the festive season playing catch-up!]

One of the highlights this week is the proof that biphosphonates, used in breast cancer that has spread to the bones, can also prolong survival.  But before you all go out and get the family pack, please note that one of the possible side-effects of biphosphonates is osteonecrosis of the jaw (localised death of bone tissue).

There’s also more evidence to show that mindfulness meditation can affect the body at the cellular level.

fosamax

image credit: presstv.ir

 

1.  Biphosphonates can act on breast cancer tumours and prolong survival

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Fulda 2013 conference #5: Oxidative stress and the EDIM (tumour-marker) test (Dr Michael Schoenberg)

(This talk was given in Fulda in Dec 2013, and delivered in German, with a simultaneous English translation, so apologies if I misunderstood any of the translation, and for the sparseness of my notes)

ChristmasMarket5

The Christmas market at Fulda

Dr Schoneberg studied Roman Catholic Theology and philosophy in Halle and Erfurt, and was a Catholic Priest in Erfurt.  He subsequently studied medicine at Martin-Luther University in Halle-Wittenberg.  He is a medical specialist in surgery in Frankfurt, and holds a doctorate in medicine.  He is medical director for emergency medical services, and also senior emergency physician.  He runs a private medical clinic for alternative medicine.

http://www.dr-schoneberg.de

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The aim of the talk was to show the relationship between a set of diagnostic tumour-marker tests, the EDIM, and oxidative stress in the human body.  These tests are not the usual conventional markers.  They enable the practitioner to track whether or not treatments are successful in reducing oxidative stress in the body.

What is the EDIM tumour-marker test?

EDIM is an acronym for Epitope Detection In Monocytes.  It is a set of two diagnostic tests that are alternatives to conventional tumour markers.  These two EDIM tests are the TKTL1 and Apo10 blood tests.  Research conducted into these tests seem to indicate that they can show early signs of metastasis even when established tumour markers and clinical signs and imaging (like Pet Scans) do not do so.

EDIMtests

image credit: tarvarlin.com

Apo10 is a specific tumour protein that is not normally detectable in normal cells.  TKTL1 stands for Transketolase-like 1 enzyme.  Cancer cells display high levels of glycolysis (rapid fermentation of glucose) a process which is also known as the Warburg effect – it’s what enables cancer cells to survive in the absence of oxygen.  Lactic acid is also produced by cancer cells, even in the presence of oxygen.  The lactic acid also protects the cancer cell from the body’s immune system.  The TKTL1 enzyme is responsible for this effect.

http://www.tktl1.de/?Introduction

http://www.tavarlin.com/downloads/2009PosterFIGO.pdf

http://www.tavarlin.com/downloads/FutureOncology.pdf

What is oxidative stress and its relation to redox reactions? (adapted from wikipedia)

A Redox reaction is an amalgamation of two processes:  a reduction and oxidation.  Substances that have the ability to reduce other substances (cause them to gain electrons) are said to be reductive or reducing and are known as reducing agents, reductants, or reducers..  Substances that have the ability to oxidize other substances (cause them to lose electrons) are said to be oxidative or oxidizing.

An example of oxidisation is rusting (oxygen causes the iron to rust).

An example of a redox process is photosynthesis in plants which involves the reduction of carbon dioxide into sugars and the oxidation of water into molecular oxygen.

Free radical reactions are redox reactions that occur as a part of homeostasis and killing microorganisms, where an electron detaches from a molecule and then reattaches almost instantaneously. Free radicals are a part of redox molecules and can become harmful to the human body if they do not reattach to the redox molecule or an antioxidant. Unsatisfied free radicals can spur the mutation of cells they encounter and are, thus, causes of cancer.

What is the relationship between oxidative stress and redox reactions?

Oxidative stress reflects an imbalance between a system’s ability to manage redox and any resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.

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According to Dr Schoneberg, therapies to correct oxidative stress include:

  • High dose Vitamin C and Alpha-Lipoic Acid
  • Polyphenols
  • Yoga, Tai Chi, meditation

There is a special type of oxidative stress called Nitrosativer Stress involving free radical nitric oxide (NO) and peroxynitrite derived product.

The Coy protocol uses the EDIM tests to monitor the effectiveness of treatments.  The Coy diet includes:

  • Tocotrienol (natural Vitamin E)
  • Carbohydrate reduction in the diet (1g/kg of bodyweight)
  • Omega 3 (10g/kg)
  • MCT oil
  • Lactate (to dissolve the coat around the tumour)
  • Polyphenols

Fulda 2013 conference #3: Master Amino Acid Pattern (MAP) and its special use in cancer (Prof. Dr. Maurizio Luca-Moretti)

ChristmasMarket7

The Christmas Market at Fulda

If this post has helped you, please would you help me?  I am now fundraising for cancer treatments at GoFundMe http://www.gofundme.com/78jh2w or at JustGiving:  https://www.justgiving.com/goBananasforRona

JustGiving - Sponsor me now!

[This was the keynote speaker and the first presentation on the morning of the conference, on a subject that would be a recurring theme in other presentations.  Unfortunately, Peter and I  were driving from Frankfurt, and because of traffic congestion, arrived about 30 minutes from the end of the lecture.

My apologies therefore, that my notes are incomplete, and this post therefore does not do justice to Prof Luca-Moretti’s fascinating lecture.  If anyone has a recording of the lecture, please send it to me and I will be more than happy to fill in the gaps.  This post is an amalgamation of several information handouts to give the background to the MAP and to place the talk in its context.]

The Speaker:  Professor Doctor Luca-Moretti has a doctoral degree in medicine, and is former professor for clinical nutritionat St. Thomas University in Florida.  He was also scientific director, president and CEO of the International Nutritional Research Centre (INRC) in Coral Gables, Florida.  He is the discover of Master Amino Acid Pattern (“MAP”), and has published numerous scientific publications and received international awards for his discovery relating to MAP.

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Best of Breast: news for week ending 20 December 2013

Updated March 2016 – For more information on GcMAF, please join the GcMAF and GcMAF Cancer forums on Facebook – they are closed groups, so you have to wait for your membership to be confirmed.  They contain up-to-date information on sources of GcMAF, and also feedback and contributions  by people who are using GcMAF.

A round-up of this week’s latest medical developments, culled from Google Alerts.  Again, there’s a glut from the 2013 San Antonio Breast Cancer Symposium, which is no bad thing.

At long last, and about time too:  cancer immunotherapy has been voted breakthrough of the year by Science magazine.  I’m looking forward to the day when all cancers can be prevented and cured by immune-boosting treatments, and cancer vaccines, and not surgery, chemotherapy and radiotherapy

Immunotherapy

image credit:  sciencemagazine.org

Scientists now prove that chemo-brain exists, a fact that people on chemo have known for ages.  Maybe this will mean chemo-brain will be taken seriously and more importantly, some cures will be in the pipeline.

Some interesting research on sugar and its role in cancer – the theory used to be that cancer cells were able to survive without oxygen, by converting sugar directly into energy.  New research has shown that increasing sugar metabolism in cells may be directly responsible for fuelling the growth of cancer cells.

A trial into the use of chemotherapy drug, 5FU (fluorouracil) shows that it did not add to the efficacy of treatment protocols using epirubicin and cyclophosphamide and paclitaxel (FEC +T).  I find this especially relevant because FECT is standard treatment for lymph-node positive breast cancer in the UK.  Does this mean the protocol will change?

Don’t forget to eat your tomatoes – not only is lycopene (the phytochemical contained in them) good for prostate cancer, it has now been shown to have a positive effect on the level of hormones that play a role in regulating fat and sugar metabolism in a trial involving post-menopausal women.

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